http://www.urowiki.or.kr/wiki/index.php?action=history&feed=atom&title=Pharmacodynamics%EC%97%90_%EB%94%B0%EB%A5%B8_%ED%95%AD%EC%83%9D%EC%A0%9C%EC%9D%98_%EC%A2%85%EB%A5%98 2026-05-06T06:02:59Z 이 문서의 편집 역사 MediaWiki 1.35.11 http://www.urowiki.or.kr/wiki/index.php?title=Pharmacodynamics%EC%97%90_%EB%94%B0%EB%A5%B8_%ED%95%AD%EC%83%9D%EC%A0%9C%EC%9D%98_%EC%A2%85%EB%A5%98&diff=4854&oldid=prev 2021-01-10T15:24:02Z

<p></p> <table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="ko"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← 이전 판</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2021년 1월 10일 (일) 15:24 판</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l2" >2번째 줄:</td> <td colspan="2" class="diff-lineno">2번째 줄:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* aminoglycosides, fluoroquinolones, azithromycin, metronidazole</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* aminoglycosides, fluoroquinolones, azithromycin, metronidazole</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 항균 효과가 AUC/MIC (AUIC), Peak/MIC ratio에 비례하므로 다량의 약제를 투여하여 혈중농도가 증가될수록 항균효과는 증대됨<del class="diffchange diffchange-inline">.</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 항균 효과가 AUC/MIC (AUIC), Peak/MIC ratio에 비례하므로 다량의 약제를 투여하여 혈중농도가 증가될수록 항균효과는 증대됨</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 약제 투여시 간격보다 용량이 더 중요함<del class="diffchange diffchange-inline">.</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 약제 투여시 간격보다 용량이 더 중요함</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 이 성격을 이용하여 aminoglycoside의 once daily 요법이나 azithromycin의 단회 요법이 도입됨<del class="diffchange diffchange-inline">.</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 이 성격을 이용하여 aminoglycoside의 once daily 요법이나 azithromycin의 단회 요법이 도입됨</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 용량은 그대로두고, 투여간격을 길게하여 dose modification</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 용량은 그대로두고, 투여간격을 길게하여 dose modification</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11" >11번째 줄:</td> <td colspan="2" class="diff-lineno">11번째 줄:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* beta-lactam agents (cephalosporins, penicillins, carbapenems), erythromycin, clarithromycin, vancomycin</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* beta-lactam agents (cephalosporins, penicillins, carbapenems), erythromycin, clarithromycin, vancomycin</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 약물농도가 높다고 하여 항균효과가 증대되지 않음<del class="diffchange diffchange-inline">.</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 약물농도가 높다고 하여 항균효과가 증대되지 않음</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 약물의 용량보다 투여 간격을 정확히 하는 것이 중요<del class="diffchange diffchange-inline">.</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 약물의 용량보다 투여 간격을 정확히 하는 것이 중요</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 투여간격은 그대로하고, 용량을 줄여 dose modification</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 투여간격은 그대로하고, 용량을 줄여 dose modification</div></td></tr> </table>

Sjlee http://www.urowiki.or.kr/wiki/index.php?title=Pharmacodynamics%EC%97%90_%EB%94%B0%EB%A5%B8_%ED%95%AD%EC%83%9D%EC%A0%9C%EC%9D%98_%EC%A2%85%EB%A5%98&diff=4851&oldid=prev 2021-01-10T15:19:40Z

<p><span dir="auto"><span class="autocomment">Time-dependent</span></span></p> <table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="ko"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← 이전 판</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2021년 1월 10일 (일) 15:19 판</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10" >10번째 줄:</td> <td colspan="2" class="diff-lineno">10번째 줄:</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Time-dependent==</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Time-dependent==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* beta-lactam agents (cephalosporins, penicillins), erythromycin, clarithromycin, vancomycin</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* beta-lactam agents (cephalosporins, penicillins<ins class="diffchange diffchange-inline">, carbapenems</ins>), erythromycin, clarithromycin, vancomycin</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 약물농도가 높다고 하여 항균효과가 증대되지 않음.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 약물농도가 높다고 하여 항균효과가 증대되지 않음.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 약물의 용량보다 투여 간격을 정확히 하는 것이 중요.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 약물의 용량보다 투여 간격을 정확히 하는 것이 중요.</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 투여간격은 그대로하고, 용량을 줄여 dose modification</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 신기능저하시 투여간격은 그대로하고, 용량을 줄여 dose modification</div></td></tr> </table>

Sjlee http://www.urowiki.or.kr/wiki/index.php?title=Pharmacodynamics%EC%97%90_%EB%94%B0%EB%A5%B8_%ED%95%AD%EC%83%9D%EC%A0%9C%EC%9D%98_%EC%A2%85%EB%A5%98&diff=4850&oldid=prev 2021-01-10T15:16:52Z

<p>새 문서: ==Concentration-dependent== * aminoglycosides, fluoroquinolones, azithromycin, metronidazole * 항균 효과가 AUC/MIC (AUIC), Peak/MIC ratio에 비례하므로 다량의 약제를...</p> <p><b>새 문서</b></p><div>==Concentration-dependent==<br /> <br /> * aminoglycosides, fluoroquinolones, azithromycin, metronidazole<br /> * 항균 효과가 AUC/MIC (AUIC), Peak/MIC ratio에 비례하므로 다량의 약제를 투여하여 혈중농도가 증가될수록 항균효과는 증대됨.<br /> * 약제 투여시 간격보다 용량이 더 중요함.<br /> * 이 성격을 이용하여 aminoglycoside의 once daily 요법이나 azithromycin의 단회 요법이 도입됨.<br /> * 신기능저하시 용량은 그대로두고, 투여간격을 길게하여 dose modification<br /> <br /> <br /> ==Time-dependent==<br /> <br /> * beta-lactam agents (cephalosporins, penicillins), erythromycin, clarithromycin, vancomycin<br /> * 약물농도가 높다고 하여 항균효과가 증대되지 않음.<br /> * 약물의 용량보다 투여 간격을 정확히 하는 것이 중요.<br /> * 신기능저하시 투여간격은 그대로하고, 용량을 줄여 dose modification</div>

Sjlee